This publication is for faculty, administrators, and other academic leaders who are poised to mount comprehensive STEM reforms to improve student learning and success, particularly for students from underrepresented minority groups. Based on the experiences of eleven colleges and universities in the Keck/PKAL STEM Education Effectiveness Framework project, the Guide contains advice on getting started, team and leader development, project management, and sustaining change. It also includes benchmarks, key questions for analysis, timeline information, challenge alerts to help anticipate common roadblocks, and a rubric to help campus teams gauge their progress. Examples from case studies developed by campus teams who participated in the project provide real-world illustrations. Also available in eBook Version (PDF).