This issue explores the tenets of AAC&U’s recently released 2018–22 strategic plan—We ASPIRE: Advancing Student Performance through Integration, Research, and Excellence—which at once reaffirms and renews AAC&U’s longstanding commitments, infusing them with new energy drawn from contemporary contexts. Additional articles consider the learning students need to prepare for future disruption, the prospects (and limits) of online learning, the use of campus-based cultural resources in humanities courses, and one university’s approach to infusing high-impact practices across the student experience.